Themes

Thematic Area I: New Screening Platforms

• Develop an open access chemoinformatic resource – a web-based interface for deposition of novel chemical entities (NCEs) for in silico screening – DRUG DISCOVERY PORTAL
• Identify emerging disease-relevant protein targets to align with screening resources
• Facilitate the in silico screening of NCEs
• Consolidate new processes and technologies for synchronous synthesis and screening

Thematic Area II: Provision of Chemical Tools

• Catalogue UK capability to produce small molecule chemical tools for chemogenomic study
• Identify unmet needs in chemogenomics for improved provision of known chemical entities
• Establish new mechanisms to resource the provision of known chemical entities for chemogenomic study to rapidly identify novel drugs and drug targets
• Match relevant synthetic capability with biological expertise to foster new collaborative efforts

Thematic Area III: Identify New Leads

• Improve the sharing of, and access to, research data across industry and academia
• Maintain and optimize the use of open access resources for protein structure data
• Direct screening technologies to validate new and exciting protein targets in disease-orientated therapeutic areas

Thematic Area IV: Novel Chemical Space

• Assess the role novel chemical space is likely to play in future drug discovery
• Consolidate how novel chemical space can be accessed by new processes and technologies
• Match synthetic discovery with industrial capability to open novel chemical space