News

201428OCT

28th October 2014 - 2nd Chemical Biology - Cancer Biology Meeting at University of Strathclyde

On 14th May CRUK and SMSdrug.net held a Chemical Biology – Cancer Biology meeting at the Beatson where 21 researchers from institutions across the city of Glasgow each gave a short presentation of their research interests to an audience of around 70. The purpose of the meeting was to encourage and support collaborative research in cancer at the chemical biology interface. We have had very good feedback on the event from the people who attended the meeting. The organisers of the event have fed back to the CRUK Centre management board who are also supportive of the initiative.

As a follow up, we are holding a second meeting here at Strathclyde on the 28th October. The format of the event will include more short talks from those who didn’t present at the first meeting, and key information on funding available to researchers. The flyer and web page have more details.

Please register here  if you are planning to attend the event. We will send registered attendees further details on the final programme closer to the time.

To find out more please contact us.


201406OCT

Beyond The Paper Resume And How To Develop An Online Profile As A Scientist

Many of us nowadays invest significant amounts of time in sharing our activities and opinions with friends and family via social networking tools. However, despite the availability of many platforms for scientists to connect and share with their peers in the scientific community the majority do not make use of these tools, despite their promise and potential impact and influence on our future careers. We are being indexed and exposed on the internet via our publications, presentations and data. We also have many more ways to contribute to science, to annotate and curate data, to “publish” in new ways, and many of these activities are as part of a growing crowdsourcing network.

This presentation will provide an overview of the various types of networking and collaborative sites available to scientists and ways to expose your scientific activities online. Many of these can ultimately contribute to the developing measures of you as a scientist as identified in the new world of alternative metrics. Participating offers a great opportunity to develop a scientific profile within the community and may ultimately be very beneficial, especially to scientists early in their career.


Antony Williams is the VP of Strategic Development for the Royal Society of Chemistry and manager of the cheminformatics team for the RSC.


This lecture is free to attend and all are welcome.

 

10.00 - 11.00am Monday 6th October 2014
At SIPBS HW111-114, University of Strathclyde
Directions: here 

For further information please  contact us.


201412SEP

Newsletter

The SMSdrug.net September 2014 Newsletter with a round up of news, meetings and publications by members of the network. Please follow this link to read the newsletter.

If you would like to contribute to the next Newsletter please contact us.


201407AUG

ChEMBL US Tour 2014

 

Following successful tours of universities in the UK (2013) and Europe (Spring 2014), ChEMBL are currently looking into doing a US Tour in 3Q 2014. If you are interested in getting ChEMBL to visit your institution, go to The ChEMBL-og and find out more.


201408JUL

Newsletter

The SMSdrug.net July 2014 Newsletter with a round up of news, meetings and publications by members of the network. Please follow this link to read the newsletter.

If you would like to contribute to the next Newsletter please contact us.


201408JUL

Paul Ehrlich MedChem EuroPhD Network

 

The Paul Ehrlich MedChem network has been created by a group of European Universities with PhD programs in Medicinal Chemistry, with the purpose to collaborate, interchange programmes, ideas, staff and students, and generate activities which would improve the standards of research and training in Medicinal Chemistry. It has a vision, through collaboration between public and private institutions, to train the required workforce, and to develop new knowledge in order to promote the drug discovery process.

 

For more information on the vision, mission, training opportunities and activities of this network, visit the group’s web pages


201426JUN

Radiopharmaceuticals

SMSdrug.net committee member Professor Mark Bagley is part of a new grouping investigating radiopharmaceuticals. This grouping have just published this paper and we have created a new working group web page for information on the group's activities. 

If you would like to find out more about this group please  contact us.


201419MAY

ChEMBL Tour 2014

Following the success of the 2013 ChEMBL Tour SMSdrug.net supported last year, Dr Gerard van Westen (EMBL –EBI) is going to be doing a 2014 ChEMBL tour. This year’s tour will be going to mainland Europe and some dates will include a presentation on Allosteric Modulators which will refer to this recent publication: van Westen GJP, Gaulton A, Overington JP (2014) Chemical, Target, and Bioactive Properties of Allosteric Modulation. PLoS Comput Biol 10(4): e1003559. doi:10.1371/journal.pcbi.1003559.

Dates are as follows:

19th of May – Maastricht University- Host Egon Willighagen / ChEMBL + Allosteric modulators

20th of May – Maastricht University- Host Jos Kleinjans / ChEMBL + Advanced ChEMBL

20th of May – KU Leuven - Host Pieter Annaert / ChEMBL

21st of May - University of Luxembourg - Host Reinhard Schneider / ChEMBL

22nd of May – Universiteit Antwerpen - Host Koen Augusteyns / ChEMBL

26th of May – VU University Amsterdam - Host Rob Leurs & Universiteit van Amsterdam - Host Willem Stiekema / ChEMBL + Allosteric modulators

28th of May – University of Groningen - Host Alexander Domling / ChEMBL + Advanced ChEMBL

6th of June – Utrecht University - Host Roland Pieters / ChEMBL

6th of June – Universiteit Leiden - Host Ad IJzerman / ChEMBL

17th of June – Erasmus Medical Centre, Rotterdam - Host Roland Kanaar / ChEMBL

18th of June – Radboud University Nijmegen - Host Tina Ritschel / ChEMBL + Allosteric modulators

Please contact gerardvw@ebi.ac.uk if you are interested in attending any of these dates or want to find out more about the tour.


201414MAY

CRUK Glasgow Centre and SMS Drug Network Chemical Biology-Cancer Biology Meeting

The aim of this meeting is to bring together biologists, chemists and oncologists from across Glasgow with an interest in cancer research. The format will be a series of short 5-minute “medium-speed-dating” talks that focus on presenting capabilities and defining research interests. These talks will be augmented with a networking lunch and poster session. The meeting should lead to cancer research and technologies groupings for nearby future collaborative efforts in cancer research across the city of Glasgow. The target audience is PIs, postdocs and students in cancer research at the CRUK Beatson Institute and the Universities of Glasgow and Strathclyde.

Please contact us if you are interested in attending this event.

                  


201413MAY

Newsletter

The SMSdrug.net May 2014 Newsletter with a round up of news, meetings and publications by members of the network. Please follow this link to read the newsletter.

If you would like to contribute to the next Newsletter please contact us.


201430APR

Allosteric Drug Design

As part of the Engage with Strathclyde week of events Dr Nahoum Anthony is hosting an Allosteric Drug Design seminar at the University of Strathclyde on 30th April.

The event will bring together academic and industrial researchers with interest in allosteric drug design and development with a view to identifying collaborative and funding opportunities.

Dr. Gerard JP van Westen (EBI-ChEMBL), Professor Leonardo Scapozza (University of Geneva) and Dr. Laurent Galibert (Alpine Institute for Drug Discovery) will present work covering various aspects of drug design in relation to allosteric targets to set the scene. 

This flyer has further details of the event.

If you would like to find out more about this event or register to attend please follow this link or  contact us.


201425MAR

RNA Splicing Community Newsletter

SMSdrug.net is supporting members of the UK RNA Splicing Community to meet to discuss their research. The latest newsletter has now been circulated and can be found here.

If you would like to contribute to the next newsletter please contact us.


201419MAR

Mechanisms, Regulation and Uses of OTU Deubiquitinases

We have the pleasure of hosting David Kommander (LMB Cambridge) on Wednesday 19th March to give a talk entitled:

Mechanisms, regulation and uses of OTU deubiquitinases

In TG310 14:15-15:15, Wednesday 19th March, Department of Pure and Applied Chemistry, University of Strathclyde (Directions:here

David is a Group Leader at MRC Laboratory of Molecular Biology with specific expertise in ubiquitinylation for more information click here.

If you would be interested in meeting with David on the day for a 1-2-1 discussion then please contact his host Glenn Burley


201419MAR

Newsletter

The SMSdrug.net March 2014 Newsletter with a round up of news, meetings and publications by members of the network. Please follow this link to read the newsletter.

If you would like to contribute to the next Newsletter please contact us.

 


201405MAR

Natural Products and Their Biological Targets 5th March

Professor Stephan Sieber, Technische Universität, Munchen will give a seminar at the University of Strathclyde 5th March at 2pm - 3pm. The title of the talk will be "Natural Products and Their Biological Targets". All are welcome to attend

Details for those of you who want to come along to the seminar:

Wednesday, 5th March 2014, 14:00 - 16:00, TG 314, Thomas Graham Building, University of Strathclyde. Directions: www.strath.ac.uk/maps/thomasgrahambuilding/ 

 

If you would further details please contact us.


201425FEB

BioAscent: Enabling Lead Finding Innovation

BioAscent has launched its new website. Please connect to www.bioascent.com for an overview of the different services available to customers.

BioAscent operate a full compound management, logistics and shipping service from our modern, Automated Compound Store.

Our services maximise the value of existing collections, minimising compound burn rate, increasing collection lifespan and quality. We also offer a professional Risk Management Service to enhance our clients Disaster Recovery Strategy for their priceless compound collections.
We have been selected as the Centre of Excellence for Compound Management for the IMI funded European Lead Factory, providing full management and logistics for the 500,000 Joint European Compound Collection, delivering annually to 8 European Screening sites, sufficient compounds for 48 HTS and follow up work.

We enable innovation through access to new chemical space. This can be from our own high quality, medicinal chemistry selected, BioAscent Compound Collection, or using our storage and IT systems, we can facilitate the secure sharing of partner compound collections under collaborator specific terms, with pharma, biotech or academic institutions.

Should you have any questions, please, don’t hesitate to  contact BioAscent


201421FEB

RNA Splicing Community Newsletter

SMSdrug.net is supporting members of the UK RNA Splicing Community to meet to discuss their research. The latest newsletter has now been circulated and can be found here.

If you would like to contribute to the next newsletter please contact us.


201420FEB

CRADD February 2014

he Centre for Rational Allosteric Drug Design (CRADD) Regular Meetings University of Strathclyde


20th February 2014: Speaker Lola Beltran
10.00am in SIPBS HW 323

Please contact us if you are interested in joining the group.


201413FEB

Glasgow Chemical Biology Network

Glasgow Chemical Biology Network Committee Meeting on 13th February 2014 at 4pm TG703, University of Strathclyde.

For more information on the Glasgow Chemical Biology Network please have a look at their website


201406FEB

Newsletter

The SMSdrug.net February 2014 Newsletter with a round up of news, meetings and publications by members of the network. Please follow this link to read the newsletter.

If you would like to contribute to the next Newsletter please contact us.


201424JAN

RNA Splicing Community Newsletter

SMSdrug.net is supporting members of the UK RNA Splicing Community to meet to discuss their research. The latest newsletter has now been circulated and can be found here.

If you would like to contribute to the next newsletter please contact us.


201421JAN

CRADD January 2014

The Centre for Rational Allosteric Drug Design (CRADD) Regular Meetings University of Strathclyde


21st January 2014: Speaker Tony Vassileiou
3.00pm in SIPBS HW 323

Please contact us  if you are interested in joining the group.


201303DEC

SMSdrug.net Poster

Professor Mark Bagley and Dr John Spencer presented the SMSdrug.net poster at the EPSRC Theme day in London on 3rd December. 

To see the poster, please follow this link


201326NOV

CRADD November 2013

The Centre for Rational Allosteric Drug Design (CRADD) Regular Meetings at University of Strathclyde


26th November 2013: Speaker Chris Foley

3.30pm in TG 710

Please contact us if you are interested in joining the group.


201322NOV

Dr John Spencer at Université de Strasbourg International Symposium of Metal-Mediated Chemistry

SMSdrug.net committtee member Dr John Spencer (University of Sussex) gave the presentation "Privileged Structures and Metallodrugs in Medicinal Chemistry" at Université de Strasbourg International Symposium of Metal-Mediated Chemistry.

If you want to find out more about the presentation please contact us .

 


201307NOV

Glasgow Chemical Biology Network

Jeff Evans (Beatson) presented an overview of cancer research to the Glasgow Chemical Biology Network Committee. This was followed by a round table exploring the potential opportunities for Chemical Biology research collaborations in Glasgow.

For more information on the Glasgow Chemical Biology Network please have a look at their website


201301NOV

Newsletter

SMSdrug.net November 2013 Newsletter.
Please follow this link to read the newsletter.


201325OCT

Biochemistry and Molecular Biology Subject Group Research Seminars 2013

'Developing small molecule therapies for lysosomal disorders: is there light at the end of the tunnel?' Prof Frances Platt, University of Oxford. Followed by a Round Table on Niemann Pick C Disease.

Host Dr John Spencer at University of Sussex

If you are interested in finding out more about this event please contact us .

 


201315OCT

Open Drug Discovery Event

The Open Drug Discovery event is being held at the University of Strathclyde to celebrate the launch of the new Drug Discovery Portal (DDP) Web Applications. The vision behind the DDP is to facilitate open/pre-competitive drug discovery projects. In addition to a live demonstration of the new website, Phil Jones (Director European Screening Centre Newhouse) and John Mitchell (University of St Andrews) will give presentations. This event is open to all and will be of relevance to researchers in the field of drug discovery, informatics, and those interested in open/ pre-competitive research. 

To register for this free event please follow this link or email smsdrugnet@strath.ac.uk (mailto)

Please note this event has already taken place. If you wish to find out more, please contact us .


201303OCT

CRADD Regular Meetings October 2013

The Centre for Rational Allosteric Drug Design (CRADD)Regular Meetings at University of Strathclyde

3rd October 2013: Speaker Nahoum Anthony

2.30pm in SIPBS HW510

Please contact us if you are interested in joining the group.


201309SEP

Therapeutic Strategies Targeting the Spliceosome

Alternative RNA splicing is essential for normal physiology in higher eukaryotes. It is also frequently altered in disease processes. Mutations in splicing sequences for example can alter splicing patterns resulting in the formation of aberrant protein isoforms. Such splicing processes in various diseases are numerous; therefore strategies that can manipulate splicing patterns and possibly correct aberrant splicing pathways could provide new targets for the development of new personalised medicine.

If you are interested in attending this meeting please contact smsdrugnet@strath.ac.uk.

Please note this event has already taken place. Please contact us if you are interested in joining this group. 

The meeting is supported by: SMSDrug.net and the biochemical society


201302SEP

SMSdrug.net at Society for General Microbiology at Sussex in Sept (2-4) 2013

Society for General Microbiology at Sussex in Sept (2-4) 2013.

SMSdrug.net committee members Dr John Spencer and Professor Mark C. Bagley (University of Sussex) gave the presentation “Privileged Druglike Libraries for Biological Evaluation and An Introduction to SMSdrug.net” at the conference.

The short presentation on the role of SMSdrug.net, a MRC-BBSRC-EPSRC joint initiative for bringing together chemists and biologists to collaborate on drug discovery, was given by Professor Mark Bagley. This was be followed by a short account on the types of molecules (libraries) made in the Spencer laboratory, of potential use to microbiologists for testing and as chemical tools for biological research. The libraries consist of a number of privileged scaffolds including benzodiazepines, oxazoles, pyrimidines and benzotriazepines.

For more information on the presentation please contact us.


201330AUG

CRADD Regular Meetings August 2013


The Centre for Rational Allosteric Drug Design (CRADD)Regular Meetings at University of Strathclyde


30th August 2013: Speaker Camille Indey

12.30pm in TG 703 - Lunch provided

If you are interested in joining this group please contact us.


201301AUG

Newsletter

SMSdrug.net August 2013 Newsletter.
Please follow this link to read the newsletter.


201324JUL

Publication

Full Reference:

Talapatra, S. K., N. G. Anthony, S. P. Mackay, and F. Kozielski. "Mitotic Kinesin Eg5 Overcomes Inhibition to the Phase I/Ii Clinical Candidate Sb743921 by an Allosteric Resistance Mechanism." J Med Chem 56, no. 16 (2013): 6317-29. DOI: 10.1021/jm4006274 


201316JUL

Glasgow Chemical Biology Network

The first Glasgow Chemical Biology Network Committee meeting took place on 16th July. Please have a look at the web page for more information on this grouping.


201328JUN

Dr John Spencer gives a presentation in Portugal

SMSdrug.net committee member Dr John Spencer (University of Sussex) presented “Privileged Structures and Metallodrugs in Medicinal Chemistry” at Departamento de Quimica, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Portugal.  

For more details please contact us.


201318JUN

CRADD Regular Meetings June 2013

The Centre for Rational Allosteric Drug Design (CRADD)Regular Meetings at University of Strathclyde


18th June 2013: Pharmacophores Training Workshop Dr Blair Johnston

1-5pm in CAL LAB SIPBS HW101

If you would like to find out more please contact us 


201331MAY

Prof Mark Bagley (University of Sussex) at Universiteit Gent, Belgium.

SMSdrug.net Committee Member Prof Mark Bagley (University of Sussex) gave the lecture “From Natural Product Synthesis to Chemical Intervention in Ageing” to a group of academics at Universiteit Gent, Belgium. To find out more please contact us .


201331MAY

Prof Mark Bagley (University of Sussex) at Katholieke Universiteit Leuven, Belgium

SMSdrug.net Committee Member Prof Mark Bagley (University of Sussex) gave the lecture “From Natural Product Synthesis to Chemical Intervention in Ageing” to a group of academics at Katholieke Universiteit Leuven, Belgium. To find out more please contact us .


201329MAY

Lecture Presentation University of Sussex

Lecture Presentation University of Sussex


Dr Martin Smith (University of Oxford) presentation "Ion Binding and Asymmetric Catalysis”


Hosted by Professor Mark Bagley, Dr John Spence; University of Sussex, School of Life Sciences

To find out more about the lecture program at University of Sussex, please contact us .

 


201322MAY

Lecture Presentation University of Sussex

Lecture Presentation University of Sussex


Prof Hagan Bayley (University of Oxford) presentation “Minimal artificial tissues from communicating droplet networks”


Hosted by Professor Mark Bagley, Dr John Spence; University of Sussex, School of Life Sciences

To find out more about the lecture program at University of Sussex, please contact us .


201308APR

ChEMBL Tour 8th - 18th April 2013

SMSdrug.net is supporting a UK wide tour of University Chemistry departments by Louisa Bellis(EBI-EMBL) to showcase the ChEMBL database.


ChEMBL is a database of over 1 million bioactive drug-like small molecules and contains 2-D structures, calculated properties (e.g. logP, Molecular Weight, Lipinski Parameters, etc.) and abstracted bioactivities (e.g. binding constants, pharmacology and ADMET data). It is an open-access, free resource that is currently used world-wide to aid in drug discovery.
To find out more please contact ljbellis@ebi.ac.uk

Dates and venues:

Monday 8th April 2013 University of Edinburgh
Tuesday 9th April 2013 University of Strathclyde
Wednesday 10th April 2013 Durham University & Newcastle University
Thursday 11th April 2013 University of Bradford & University of Sheffield
Friday 12th April 2013 University of Birmingham
Monday 15th April 2013 University of Nottingham & University of Warwick
Tuesday 16th April 2013 University of Bath & Cardiff University
Wednesday 17th April 2013 University of Southampton
Thursday 18th April 2013 University of Sussex
Friday 19th April 2013 University of Oxford

If you would like a copy of the slides from the ChEMBL tour, please contact us .

.

 


201305APR

A Hub for Engineering and Exploiting the Stem Cell Niche

SMSdrug.net is part of a successful bid led by Stuart Forbes, Professor of Transplantation and Regenerative Medicine at the University of Edinburgh’s for a MRC Centre for Regenerative Medicine (CRM): A Hub for Engineering and Exploiting the Stem Cell Niche.
The £4.5M research project, which will start later this year, will be carried out in collaboration with the University of Manchester, Imperial College London, University of Bristol, King’s College London, University of Strathclyde, Keele University and the University of Cambridge.
For further details on the award see the following link 


201301APR

Newsletter

SMSdrug.net May 2013 Newsletter.
Please follow this link to read the newsletter.


201331MAR

Mackay et al IKKalpha double grant awarded by Prostate Cancer UK and MRC

Of the 1 in 6 men diagnosed with prostate cancer, 1 in 33 will die of metastatic disease. IKKα represents a viable therapeutic target in CRPC which has been vindicated in mouse models of prostate cancer. Through access to a unique matched hormone-naïve and CRPC cohort, Professor Simon Mackay's group (University of Strathclyde) has linked these findings with clinical data to highlight the central role played by IKKα in the development of CRPC and metastasis.

Targeting the single IKKα isoform would also bring the benefit of a reduced side-effect profile by avoiding IKKα inhibition. To date, there are no reported selective inhibitors of IKKα
With funding from Cancer Research UK, the group has generated a potent IKKα selective lead series with selectivity over IKKα that is recapitulated in the cellular environment. They have just been awarded £249,000 and £111,000 from Prostate Cancer UK and MRC to continue the lead optimisation phase of combining desirable ADME properties with potency for in vivo efficacy studies to drive a further round of optimisation to progress towards a first-in-class pre-clinical candidate.

To find out more, please contact us .


201313MAR

Lecture Presentation University of Sussex

Lecture Presentation University of Sussex


Dr William Chain (University of Hawaii) presentation “Chemistry and biology of englerin A”


Hosted by Dr John Spence; University of Sussex, School of Life Sciences

To find out more about the lecture program at University of Sussex, please contact us .

 


201306MAR

Lecture Presentation University of Sussex

Lecture Presentation University of Sussex


Prof John Murphy (University of Strathclyde) presentation “Highly Reactive Nitrogen Heterocycles –Synthesis and Properties”

Hosted by Professor Mark Bagley, Dr John Spence; University of Sussex, School of Life Sciences

To find out more about the lecture program at University of Sussex, please contact us .


201301MAR

SMSdrug.net Newsletter

SMSdrug.net March 2013 Newsletter.
Please follow this link to read the newsletter.


201320FEB

Lecture Presentation University of Sussex

Lecture Presentation University of Sussex


Dr Stuart Conway (University of Oxford) presentation “Chemistry Illuminating Biology: the Design and Synthesis of Chemical probes for Biological Systems”


Hosted by Professor Mark Bagley, Dr John Spence; University of Sussex, School of Life Sciences

To find out more about the lecture program at University of Sussex, please contact us .


201318FEB

Using synthetic biology to dial a molecule: defining the path to success

Using synthetic biology to dial a molecule: defining the path to success
Dial-a-molecule, SMSdrug.net, GSK
SMSdrug.net PI Professor Nicholas Tomkinson (University of Strathclyde chaired a session at the meeting. For more information please follow this link.


201313FEB

Lecture Presentation University of Sussex

Lecture Presentation University of Sussex

Prof John Storey (University of Aberdeen) presentation “Alzheimer’s Disease; from Bench to Bedside”

Hosted by Professor Mark Bagley, Dr John Spence; University of Sussex, School of Life Sciences

To find out more about the lecture program at University of Sussex, please contact us .


201308FEB

SMSdrug.net Outreach

On 8th February 2013, SMSdrug.net committee member Professor Mark Bagley (university of Sussex) gave the presentation “What’s the Use of Chemistry?” to an audience of 40 pupils at Sir George-Monoux 6th Form College.

To find out more, please contact us .


201305FEB

5th February 2013 Drug discovery: Leveraging academic impact through novel fragments

Drug discovery: Leveraging academic impact through novel fragments
Tue 05 Feb 2013 - 3M Buckley Innovation Centre, Huddersfield

Given the UK strength in chemical synthesis, a chemical consortium focused upon the implementation of powerful synthetic methods would be perfectly placed to design and deliver novel three-dimensional chemical libraries for fragment screening to complement existing fragment libraries. The consortium would also be able to contribute to the generation of useful chemical start points for a broad range of target therapeutic classes.

In collaboration with the ‘Dial-a-Molecule’ EPSRC Grand Challenge Network and SMSDrug.net, on 5 February 2013 the 3D Fragment Consortium will host a workshop meeting at which the opportunities and benefits for academic synthetic chemists will be presented. In particular, the workshop will discuss:

  • how class-leading academic synthesis can be used in a drug discovery context
  • the key features of fragment libraries, and their relevance to cutting-edge research groups
  • the tools available to enable synthetic chemists to make contributions to the drug discovery process constructing an inclusive network of med chem-facing academic chemists
  • funding possibilities how to deal with IP issues.


For further information, please contact us .


201302FEB

3rd UK RNA Splicing Workshop

SMSdrug.net supports a session at the 3rd UK RNA Splicing Workshop 1st – 3rd February 2013 Rydal Hall, Cumbria, UK
Organisers: David Elliott and Chris Smith
Sponsors: The Genetics Society
British Society For Cell Biology
Biochemical Society
SMSdrug.net

The sponsored session was supported as a follow up to the meeting "Therapeutic Strategies Targeting the Spliceosome" held in December 2012 at the RSC. 

To find out more, please contact us .

 


201316JAN

16th January 2013 Dr Neil Carragher Presentation at University of Strathclyde

Dr Neil Carragher from Edinburgh Cancer Research UK centre will be visiting us on 16th January hosted by RICAS, SMSdrug.net and WestChem: talk at 1.pm on January 16th in SIPBS HW113 and all are welcome.

Neil will be delivering his presentation entitled:

"Imaging and Pathway Profiling: Advancing cancer drug discovery towards improved clinical efficacy"

To find out more, please contact us .


201315JAN

CRADD Regular Meetings January 2013

The Centre for Rational Allosteric Drug Design(CRADD) Regular Meetings at University of Strathclyde.

16th January 2013: Speaker is Dr Blair Johnston

9am in  TG703

Please contact us if you are interested in joining the group.

 

 


201304JAN

SMSdrug.net Presentations at RSC Heterocyclic and Synthesis Group

SMSdrug.net committee members Prof Mark Bagley and Dr John Spencer attended the RSC Heterocyclic and Synthesis Group, January meeting 2013, QMUL. where98 participants from academia and industry were present. 

The presentations:

“Heterocycles for Chemical Intervention in Ageing” Prof Mark Bagley (University of Sussex)

 “Parallel Synthetic Routes to Heterocycles of Biological Importance” Dr John Spencer (University of Sussex)

 

To find out more, please contact us .


201220DEC

SMSdrug.net Newsletter

SMSdrug.net December 2012 Newsletter.
Please follow this link to read the newsletter.


201210DEC

Therapeutic Strategies Targetting The Spiceosome

Alternative RNA splicing is essential for normal physiology in higher eukaryotes. It is also frequently altered in disease processes. Mutations in splicing sequences for example can alter splicing patterns resulting in the formation of aberrant protein isoforms. Such splicing processes in various diseases are numerous, including up to 15% of all cancers. Therefore strategies that can manipulate splicing patterns and possibly correct aberrant splicing pathways could provide new targets for the development of new personalised medicine. This group has three meetings planned over the next 18 months, with the first happening at the RSC Chemistry Centre, Burlington house on December 10th 2012.

Agenda

RNA Splicing pages link

Tofind out more about the RNA Splicing group, please contact us .

 


201205DEC

Allostery Working Group Meeting

Allostery Working Group Meeting at University of Edinburgh

The working group brings together experts in technologies, modelling and informatics, screening, structural biology and chemistry together with the aim of drafting a funding proposal and targeting funding opportunities to enable a paradigm shift in allosteric drug discovery research. A first draft of the proposal will be circulated prior to the meeting.

If you would like access to outcomes from this meeting or to find out more about the Allostery group, please contact us .


201205DEC

Lecture Presentation University of Sussex

Lecture Presentation Univesity of Sussex


Prof Kamyar Afarinkia (University of Bradford) presentation “Synthesis and Evaluation of New Cancer Medicines”

Hosted by: Mark Bagley, John Spencer; University of Sussex, School of Life Sciences

To find out more about the lecture program at University of Sussex, please contact us .


201204DEC

Allostery Workshop

An Allostery Workshop is taking place at the University of Edinburgh on 4th December 2012 . The Workshop, sponsored by the British Council, TPP Global and SMSdrug.net includes an extensive delegation of scientists from Turkey led by Burak Erman, Koc University, Istanbul and will bring together a diverse area of disciplines including Biology, Chemistry, Computer Science, Informatics, Mathematics and Medicine. The program for the day will include presentations and poster session.

Allostery One Day Conference Programme - 4th Dec 2012

The workshop is now fully subscribed.

To find out more about the Allostery group, please contact us .

 


201221NOV

Lecture Presentation University of Sussex

Lecture Presentation byDr Andrew Wilson (University of Leeds): “Adventures in Non-Covalent Chemisty: From Self-Assembly to Protein-Surface Recognition”

Hosted by: Mark Bagley, John Spencer; University of Sussex, School of Life Sciences

To find out more about the lecture program at University of Sussex, please contact us .


201209NOV

University of Sussex News

Speakers at Sussex (12 -1 pm, Wednesdays):

November:

7th Nov: Prof Mark Moloney (Oxford) “Equisetin, Reutericyclin and Streptolodygin: Natural Product Lead Structures for Novel Antibiotics”

21st Nov: Dr Andrew Wilson (Leeds) “Adventures in Non-Covalent Chemisty: From Self-Assembly to Protein-Surface Recognition”.

December:

5th Dec: Prof Kamyar Afarinkia (Bradford) “Synthesis and Evaluation of New Cancer Medicines”.

12th Dec: Prof Fran Platt (Oxford) “ Lysomomal Disorders and Treatments”

 

Next term’s speaker list is in preparation but we have the following speakers confirmed:

Prof Hayden Bayley (Oxford), Prof John Storey (Aberdeen), Dr Stuart Conway (Oxford)

To find out more about the lecture program at University of Sussex, please contact us .


201207NOV

Lecture Presentation University of Sussex

Lecture Presentation by Prof Mark Moloney (University of Oxford): “Equisetin, Reutericyclin and Streptolodygin: Natural Product Lead Structures for Novel Antibiotics”

Hosted by Professor Mark Bagley, Dr John Spencer; University of Sussex, School of Life Sciences

To find out more about the lecture program at University of Sussex, please contact us .


201206NOV

CRADD Regular Meetings November 2012

The Centre for Rational Allosteric Drug Design (CRADD) Regular Meetings at the University of Strathclyde.

5th November 2012: Speaker is Dr Mark Dufton

9am in  TG 703

 

Please contact us if you are interested in joining the group.

 


201205NOV

SMSdrug.net Newsletter

SMSdrug.net November 2012 Newsletter.

Please follow this link to read the newsletter.


201228OCT

Chemical Biology Networks Meeting


201226OCT

SMSdrug.net 2011 - 2012 Annual Summary Available

SMSdrug.net 2011 - 2012 Annual Summary Available here.

 


201210OCT

CRADD Regular Meetings Launch October 2012

The Centre for Rational Allosteric Drug Design (CRADD) Regular Meetings at University of Strathclyde: Launch

10th October 2012: Speaker is Nizar Al-Shar'i

3pm in TG703

Please contact us if you are interested in joining the group.


201227SEP

Relevant Challenges in Chemical Biology

SMSDrug.net meeting on 27th Septmeber 2012 discussed how academic researchers and industrial partners can work effectively together in early stage drug discovery. Identifying the most relevant chemical biology challenges from an industry perspective is an important first step in developing successful research partnerships. The discussion focussed on challenges academic researchers could tackle from the perspective of the pharmaceutical industry in both the short and longer term. The outcomes of the meeting will be used to provide focus to the members of the network.

If you would like access to outcomes from this meeting please join the members area or contact us .


201210SEP

UK Chemical Biology Networks AGM

UK Chemical Biology Networks Meeting 
3D FragAGRI-netCCPD; MCBN; PCB netPPI-Net; SMSdrug.net.


201229JUN

Predictive and Rational Allosteric Site Identification

Round Table Discussion meeting on Friday 29th June 2012 at RSC in London chaired by Nick Tomkinson. 

It is proposed to bring together a round table discussion with experts in technologies, modelling and informatics, screening, structural biology and chemistry together with experienced industrialists with the aim of identifying and targeting funding opportunities to enable a paradigm shift in allosteric drug discovery research.

If you would like access to outcomes from this meeting please join the members area or contact us .


201213JUN

UK Chemical Biology Networks Meeting

UK Chemical Biology Networks Meeting 
3D FragAGRI-netCCPD; MCBN; PCB netPPI-Net; SMSdrug.net.


201212JUN

Matchmaking Ethical Medium Throughput Screening with Chemistry

June 12th 2012 Round Discussion At RSC Chemistry Centre, London in partnership with RSC CBID.

This round table discussion will develop an understanding and identify opportunities at the Chemistry/Life Science interface to promote and develop collaborative research with respect to Ethical Medium Throughput Screening.

If you would like access to outcomes from this meeting please join the members area or contact us .


201230MAY

Call for Proposals for Round Table Discussion Group Meetings

SMSDrug.net would like to invite proposals for Round Table Discussion Groups. SMSDrug.net will support Round Table Discussions Groups where participants meet to discuss a drug discovery topic. Participants are requested to inform each other about their work, identify challenges that need to be solved, and establish areas where collaborative efforts could be nurtured in relation to the chosen topic.

SMSDrug.net will support successful applications by refunding the costs of participants travel (within UK) and reasonable catering costs for the meeting.

To make an application please download the application form and return the completed form to smsdrugnet@strath.ac.uk

SMSDrug Round Table Discussion Groups Application Form


201204MAY

Identifying and Developing Opportunities at the Chemistry Life Science Interface

This round table discussion will develop an understanding and identify opportunities at the Chemistry/Life Science interface to promote and develop collaborative research.

If you would like access to outcomes from this meeting please join the members area or contact us .

 


201202MAY

SMSdrug.net Flyer

SMSdrug.net flyer available to download here.

To find out more about the network please contact us .


201212APR

Allosterism

The meeting aims to discuss opportunities for a collaborative approach to develop a centre for rational allosteric drug discovery. To identify important themes/concepts that should be included within this grouping and to identify personnel/expertise that should be involved. 

To find out more about the Allostery Group, please contact us .

 


201202MAR

UK Chemical Biology Networks Meeting

UK Chemical Biology Networks Meeting 
3D FragAGRI-netCCPD; MCBN; PCB netPPI-Net; SMSdrug.net.


201104SEP

Publication

Full Reference:

Miduturu, C. V., X. Deng, N. Kwiatkowski, W. Yang, L. Brault, P. Filippakopoulos, E. Chung, Q. Yang, J. Schwaller, S. Knapp, R. W. King, J. D. Lee, S. Herrgard, P. Zarrinkar, and N. S. Gray. "High-Throughput Kinase Profiling: A More Efficient Approach toward the Discovery of New Kinase Inhibitors." Chem Biol 18, no. 7 (2011): 868-79. DOI: 10.1016/j.chembiol.2011.05.010 


201104SEP

SMSdrug.net Grant Awarded

SMSdrug.net awarded grant by EPSRC. The grant runs from 1st Setember 2011 to 31st August 2015 and will support the establishment of an Academic - User network in UK drug discovery:"The Alignment of Synthesis, Medicinal Chemistry and Structural Biology - SMSdrug.net"


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