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Three recent publications from the UK RNA Splicing Community:
Mike Gait’s group have recently published an article in Org. Biomol. Chem.
Parallel synthesis and splicing redirection activity of cell-penetrating peptide conjugate libraries of a PNA cargo. P.J. Deuss, A.A Arzumanov, D.L. Williams and M.J. Gait Org Biomol. Chem., (2013) DOI:10.1039/C3OB41659C.
This is a method of chemical synthesis of libraries of peptide conjugates of biocargoes (of which splice-redirecting PNA is an example) for parallel cell assays. The method has been patented and licensed to Cambridge Research Biochemicals for people to commission synthetic libraries for screening. Currently the method is useful to make peptide conjugate libraries of PNA, PMO and peptide cargoes but can in principle be modified for use with other oligo types and siRNA.
Cyril Dominguez’ group have recently published a method paper describing their NMR strategies to study protein RNA complexes. The article can be found at: http://www.ncbi.nlm.nih.gov/pubmed/24096002
Screening protein – Single stranded RNA complexes by NMR spectroscopy for structure determination. Foot JN, Feracci M, Dominguez C. Methods. 2013 Oct 1. pii: S1046-2023(13)00387-3. doi: 10.1016/j.ymeth.2013.09.018. [Epub ahead of print]
Dave Bates et al have published a paper which might be of interest, and was facilitated by SMSdrug.net interactions.
Topical anti-angiogenic SRPK1 inhibitors reduce choroidal neovascularization in rodent models of exudative-AMD. Gammons MV, Federov O, Ivison D, Du C, Clark TL, Hopkins C, Hagiwara M, Dick AD, Cox RJ, Harper SJ, Hancox JC, Knapp S, Bates DO. Invest Ophthalmol Vis Sci. 2013 Jul 25. doi:pii: iovs.13-12422v1. 10.1167/iovs.13-12422. [Epub ahead of print] PMID: 23887803
The Drug Discovery Portal (DDP) provides users with the opportunity to identify novel druggable hits against their target of choice through virtual screening. The DDP has now been developed so that users can directly use the tools via the web. All you need to do to use this free resource is become a member of the new website. For more information on this exciting new tool, please come along to the Open Drug Discovery event on 15th October at the University of Strathclyde, where a live demo of the new website will take place.