Circadian Drug Discovery

Humans are rhythmic beings, with daily sleep/wake cycles affecting almost every aspect of physiology and behaviour. In harmony with the natural day/night cycle, our internal clock regulates when we sleep, when we eat, and when we are active. Disruption of this clock has been linked to numerous chronic disease states, metabolic disorders and ageing, suggesting a profound impact on human health. The possibility of influencing the biological clock using small molecules represents an exciting opportunity for the development of new medicines. has provided funds for an international working group involving industrial and academic scientists from the USA and UK to develop innovative approaches to validating these emerging therapeutic targets.

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